Article
Impact of CYP2E1, GSTA1 and GSTP1 gene variants on serum alpha glutathione S-transferase level in patients undergoing anaesthesia.
BMC medical genetics - 14 May 2016
Mikstacki Adam, Skrzypczak-Zielinska Marzena, Zakerska-Banaszak Oliwia, Tamowicz Barbara, Skibinska Maria, Molinska-Glura Marta, Szalata Marlena, Slomski Ryszard
Abstract excerpt
BACKGROUND: The serum glutathione S-transferase alpha (α-GST) concentration has been used as a marker of hepatic condition. After sevoflurane anaesthesia a mild impairment of hepatocellular integrity was observed. Genetic polymorphisms in CYP2E1, GSTA1 and GSTP1 genes, affecting enzymes activity, may possibly influence the hepatotoxic effect of sevoflurane. The aim of this study was to assess the influence of...
Topics
- Adult
- Aged
- Anesthesia, General
- Cytochrome P-450 CYP2E1
- Female
- Glutathione S-Transferase pi
- Glutathione Transferase
- High-Throughput Nucleotide Sequencing
- Humans
- Isoenzymes
- Liver
- Male
- Methyl Ethers