Article
TNF-α -857C>T genotype is predictive of clinical response after treatment with definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.
International journal of medical sciences - 1 Jan 2013
Omatsu Hideaki, Kuwahara Akiko, Yamamori Motohiro, Fujita Megumi, Okuno Tatsuya, Miki Ikuya, Tamura Takao, Nishiguchi Kohshi, Okamura Noboru, Nakamura Tsutomu, Azuma Takeshi, Hirano Takeshi, Ozawa Koichiro, Hirai Midori
Abstract excerpt
BACKGROUND: Genotypes of tumor necrosis factor alpha (TNF-α) and its surface receptors, TNFRSF1A and TNFRSF1B, have been examined in terms of the progression, metastasis, clinical efficacy, and prognosis of various cancers; however, little is known about their effects on clinical outcome in patients with esophageal squamous cell carcinoma (ESCC). In this study, TNF-α and TNFRSF1A genotypes were retrospectively...
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