Article
Genetic polymorphisms in SLC23A2 as predictive biomarkers of severe acute toxicities after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.
International journal of medical sciences - 1 Jan 2014
Minegaki Tetsuya, Kuwahara Akiko, Yamamori Motohiro, Nakamura Tsutomu, Okuno Tatsuya, Miki Ikuya, Omatsu Hideaki, Tamura Takao, Hirai Midori, Azuma Takeshi, Sakaeda Toshiyuki, Nishiguchi Kohshi
Abstract excerpt
OBJECTIVE: Definitive chemoradiotherapy (CRT) with 5-fluorouracil (5-FU) and cisplatin (CDDP) is one of the standard therapies for esophageal squamous cell carcinoma (ESCC); however, inter-individual variations in clinical outcomes have yet to be investigated. In the present study, single nucleotide polymorphisms (SNPs) in SLC23A2 gene were retrospectively evaluated in 49 Japanese patients with ESCC who were...
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