A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma.

doi:10.1371/journal.pone.0109318

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Article

A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma.

PloS one - 1 Jan 2014

Zhang Jian, Yu Hongchen, Zhang Yi, Zhang Xiaoshi, Zheng Guixin, Gao Yang, Wang Chuanxin, Zhou Liqing

Abstract excerpt

BACKGROUND: Accumulated evidences demonstrated that single nucleotide polymorphisms (SNPs) in mRNA 3'-untranslated region (3'-UTR) may impact microRNAs (miRNAs)-mediated expression regulation of oncogenes and tumor suppressors. There is a TNFAIP2 3'-UTR rs8126 T>C genetic variant which has been proved to be associated with head and neck cancer susceptibility. This SNP could disturb binding of miR-184 with TNFAIP2...

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PMID: 25383966
DOI: 10.1371/journal.pone.0109318
PMCID: PMC4226436

Genes

TNFAIP2

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