Article
A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma.
PloS one - 1 Jan 2014
Zhang Jian, Yu Hongchen, Zhang Yi, Zhang Xiaoshi, Zheng Guixin, Gao Yang, Wang Chuanxin, Zhou Liqing
Abstract excerpt
BACKGROUND: Accumulated evidences demonstrated that single nucleotide polymorphisms (SNPs) in mRNA 3'-untranslated region (3'-UTR) may impact microRNAs (miRNAs)-mediated expression regulation of oncogenes and tumor suppressors. There is a TNFAIP2 3'-UTR rs8126 T>C genetic variant which has been proved to be associated with head and neck cancer susceptibility. This SNP could disturb binding of miR-184 with TNFAIP2...
Topics
- 3' Untranslated Regions
- Asian People
- Carcinoma, Squamous Cell
- Cytokines
- Esophageal Neoplasms
- Esophageal Squamous Cell Carcinoma
- Genotype
- Humans
- Odds Ratio
- Polymorphism, Single Nucleotide
- Real-Time Polymerase Chain Reaction