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Article

Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.

PloS one - 1 Jan 2015

Abe Koichiro, Takamatsu Nobuhiko, Ishikawa Kumiko, Tsurumi Toshiko, Tanimoto Sho, Sakurai Yukina, Lisse Thomas S, Lisse Thomas, Imai Kenji, Serikawa Tadao, Mashimo Tomoji

Abstract excerpt

Congenital vertebral malformations caused by embryonic segmentation defects are relatively common in humans and domestic animals. Although reverse genetics approaches in mice have provided information on the molecular mechanisms of embryonic somite segmentation, hypothesis-driven approaches cannot adequately reflect human dysmorphology within the population. In a N-ethyl-N-nitrosourea (ENU) mutagenesis project in...

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Identifiers

PMID: 26090680
DOI: 10.1371/journal.pone.0130231
PMCID: PMC4474719

Genes

TBX6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat.PMID 26090680Read ↗

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