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Article

Differential effect of three‐repeat and four‐repeat tau on mitochondrial axonal transport

3 Aug 2009

Abstract excerpt

Tau protein is present in six different splice forms in the human brain and interacts with microtubules via either 3 or 4 microtubule binding repeats. An increased ratio of 3 repeat to 4 repeat isoforms is associated with neurodegeneration in inherited forms of frontotemporal dementia. Tau over-expression diminishes axonal transport in several systems, but differential effects of 3 repeat and 4 repeat isoforms...

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PMID: 19686388
DOI: 10.1111/j.1471-4159.2009.06316.x

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