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Article

Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2P497H Mutation.

International journal of molecular sciences - 26 Sept 2022

Zhang Yiti, Zeng Baitao, Gu Ao, Kang Qinyu, Zhao Mingri, Peng Guangnan, Zhou Miaojin, Liu Wanxi, Liu Min, Ding Lingjie, Liang Desheng, Liu Xionghao, Liu Mujun

Abstract excerpt

Ubiquilin-2 (UBQLN2) mutations lead to familial amyotrophic lateral sclerosis (FALS)/and frontotemporal dementia (FTLD) through unknown mechanisms. The combination of iPSC technology and CRISPR-mediated genome editing technology can generate an iPSC-derived motor neuron (iPSC-MN) model with disease-relevant mutations, which results in increased opportunities for disease mechanism research and drug screening. In...

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Identifiers

PMID: 36232630
DOI: 10.3390/ijms231911333
PMCID: PMC9570184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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