Article
LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.
Human molecular genetics - 15 Nov 2017
Howlett Evan H, Jensen Nicholas, Belmonte Frances, Zafar Faria, Hu Xiaoping, Kluss Jillian, Schüle Birgitt, Kaufman Brett A, Greenamyre J T, Sanders Laurie H
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with increased risk for developing Parkinson's disease (PD). Previously, we found that LRRK2 G2019S mutation carriers have increased mitochondrial DNA (mtDNA) damage and after zinc finger nuclease-mediated gene mutation correction, mtDNA damage was no longer detectable. While the mtDNA damage phenotype can be unambiguously attributed to the LRRK2...
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