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Article

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity.

Scientific reports - 21 Jul 2017

Stelma Femke, de Niet Annikki, Sinnige Marjan J, van Dort Karel A, van Gisbergen Klaas P J M, Verheij Joanne, van Leeuwen Ester M M, Kootstra Neeltje A, Reesink Hendrik W

Abstract excerpt

Tissue resident memory T cells (TRM) have been identified in various tissues, however human liver TRM to date remain unidentified. TRM can be recognized by CD69 and/or CD103 expression and may play a role in the pathology of chronic hepatitis B (CHB) and hepatitis C virus infection (CHC). Liver and paired blood mononuclear cells from 17 patients (including 4 CHB and 6 CHC patients) were isolated and CD8+ T cells...

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Share to Antigens, Differentiation, T-Lymphocyte
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Immunologic Memory

Share to Integrin alpha Chains

Share to Kruppel-Like Transcription Factors

Share to Lectins, C-Type

Share to Leukocytes, Mononuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 28733665
DOI: 10.1038/s41598-017-06352-3
PMCID: PMC5522381

Genes

CXCR6
KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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