Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.

doi:10.1158/1055-9965.EPI-10-1224

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Article

Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2011

Permuth-Wey Jennifer, Chen Y Ann, Tsai Ya-Yu, Chen Zhihua, Qu Xiaotao, Lancaster Johnathan M, Stockwell Heather, Dagne Getachew, Iversen Edwin, Risch Harvey, Barnholtz-Sloan Jill, Cunningham Julie M, Vierkant Robert A, Fridley Brooke L, Sutphen Rebecca, McLaughlin John, Narod Steven A, Goode Ellen L, Schildkraut Joellen M, Fenstermacher David, Phelan Catherine M, Sellers Thomas A

Abstract excerpt

BACKGROUND: Mitochondria contribute to oxidative stress, a phenomenon implicated in ovarian carcinogenesis. We hypothesized that inherited variants in mitochondrial-related genes influence epithelial ovarian cancer (EOC) susceptibility. METHODS: Through a multicenter study of 1,815 Caucasian EOC cases and 1,900 controls, we investigated associations between EOC risk and 128 single nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 21447778
DOI: 10.1158/1055-9965.EPI-10-1224
PMCID: PMC3111851

Genes

ESRRA
IMPACT
NRF1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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