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Article

The transcriptional repressor domain of Gli3 is intrinsically disordered.

PloS one - 1 Jan 2013

Tsanev Robert, Vanatalu Kalju, Jarvet Jüri, Tanner Risto, Laur Kristi, Tiigimägi Piret, Kragelund Birthe B, Østerlund Torben, Kogerman Priit

Abstract excerpt

The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway. Gli3 contains a repressor domain in its N-terminus from residue G106 to E236. In this study we have characterized the intracellular structure of the Gli3 repressor domain using a combined bioinformatics and experimental approach. According to our findings the Gli3 repressor domain while...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24146948
DOI: 10.1371/journal.pone.0076972
PMCID: PMC3798401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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