Article

Gain-of-function mutation in <i>Gli3</i> causes ventricular septal defects

2020-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Ventricular septal defects (VSDs) are developmental disorders, characterised by a gap in the septum between the right and the left ventricle, that lead to life-threatening heart defects. At present, the only curative treatment of VSDs is surgical closure. Since these surgeries comprise several severe risks, the development of alternative therapies against VSDs is urgently needed. To develop such...

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Literature Corpus work: 4f62516b-03d0-5ba6-a408-a3d6dd39da4d
DOI: 10.1101/2020.02.10.942144

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