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Article

Functional analysis of the zinc finger and activation domains of Glis3 and mutant Glis3(NDH1).

Nucleic acids research - 1 Mar 2008

Beak Ju Youn, Kang Hong Soon, Kim Yong-Sik, Jetten Anton M

Abstract excerpt

The Krüppel-like zinc finger protein Gli-similar 3 (Glis3) plays a critical role in pancreatic development and has been implicated in a syndrome with neonatal diabetes and hypothyroidism (NDH). In this study, we examine three steps critical in the mechanism of the transcriptional regulation by Glis3: its translocation to the nucleus, DNA binding and transcriptional activity. We demonstrate that the putative...

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Identifiers

PMID: 18263616
DOI: 10.1093/nar/gkn009
PMCID: PMC2275160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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