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Article

SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers.

Scientific reports - 22 Oct 2013

Matsuura Shun, Kahyo Tomoaki, Shinmura Kazuya, Iwaizumi Moriya, Yamada Hidetaka, Funai Kazuhito, Kobayashi Jun, Tanahashi Masayuki, Niwa Hiroshi, Ogawa Hiroshi, Takahashi Takashi, Inui Naoki, Suda Takafumi, Chida Kingo, Watanabe Yoshinori, Sugimura Haruhiko

Abstract excerpt

Mitosis is the most conspicuous cell cycle phase and Shugoshin-like 1 (SGOL1) is a key protein in protecting sister chromatids from precocious separation during mitosis. We studied the role of SGOL1 and its splice variants in non-small cell lung cancer (NSCLC) using 82 frozen NSCLC tissue samples. SGOL1-B expression was prevalent in smokers, in cases with a wild-type (WT) EGFR status, and in cases with the focal...

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Open in PubMed Open full text

Identifiers

PMID: 24146025
DOI: 10.1038/srep03012
PMCID: PMC3804856

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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