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Article

Downregulation of CASR expression and global loss of parafibromin staining are strong negative determinants of prognosis in parathyroid carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2011

Witteveen Janneke E, Hamdy Neveen A T, Dekkers Olaf M, Kievit Job, van Wezel Tom, Teh Bin T, Romijn Johannes A, Morreau Hans

Abstract excerpt

Parathyroid carcinoma is associated with mutations in the HRPT2/CDC73 gene and with decreased parafibromin and calcium-sensing receptor (CASR) expression, but in some cases establishing an unequivocal diagnosis remains a challenge. The aim of our study was to evaluate the prognostic value of CASR and parafibromin expression and of HRPT2/CDC73 mutations in patients with an established diagnosis of parathyroid...

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Source

Identifiers

PMID: 21240254
DOI: 10.1038/modpathol.2010.236

Genes

CASR
CDC73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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