Article
Novel HRPT2/CDC73 gene mutations and loss of expression of parafibromin in Chinese patients with clinically sporadic parathyroid carcinomas.
PloS one - 1 Jan 2012
Wang Ou, Wang Chunyan, Nie Min, Cui Quancai, Guan Heng, Jiang Yan, Li Mei, Xia Weibo, Meng Xunwu, Xing Xiaoping
Abstract excerpt
OBJECTIVE: It is widely recognized that the diagnosis of parathyroid carcinoma (PC) is often difficult because of the overlap of characteristics between malignant and benign parathyroid tumors, especially at an early stage. Based on the identification of tumor suppressor gene HRPT2/CDC73 and its association with hereditary and sporadic PC, screening of gene mutations and detection of parafibromin immunoreactivity...
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