Article
Genomic instability: a stronger prognostic marker than proliferation for early stage luminal breast carcinomas.
PloS one - 1 Jan 2013
Vincent-Salomon Anne, Benhamo Vanessa, Gravier Eléonore, Rigaill Guillem, Gruel Nadège, Robin Stéphane, de Rycke Yann, Mariani Odette, Pierron Gaëlle, Gentien David, Reyal Fabien, Cottu Paul, Fourquet Alain, Rouzier Roman, Sastre-Garau Xavier, Delattre Olivier
Abstract excerpt
BACKGROUND: The accurate prognosis definition to tailor treatment for early luminal invasive breast carcinoma patients remains challenging. MATERIALS AND METHODS: Two hundred fourteen early luminal breast carcinomas were genotyped with single nucleotide polymorphisms (SNPs) array to determine the number of chromosomal breakpoints as a marker of genomic instability. Proliferation was assessed by KI67...
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