Article
The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer.
PloS one - 1 Jan 2013
Szász Attila Marcell, Li Qiyuan, Eklund Aron C, Sztupinszki Zsófia, Rowan Andrew, Tőkés Anna-Mária, Székely Borbála, Kiss András, Szendrői Miklós, Győrffy Balázs, Szállási Zoltán, Swanton Charles, Kulka Janina
Abstract excerpt
PURPOSE: Quantifying chromosomal instability (CIN) has both prognostic and predictive clinical utility in breast cancer. In order to establish a robust and clinically applicable gene expression-based measure of CIN, we assessed the ability of four qPCR quantified genes selected from the 70-gene Chromosomal Instability (CIN70) expression signature to stratify outcome in patients with grade 2 breast cancer....
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