Article
An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis.
BMC medical genomics - 27 Nov 2012
Bonnet Françoise, Guedj Mickael, Jones Natalie, Sfar Sana, Brouste Véronique, Elarouci Nabila, Banneau Guillaume, Orsetti Béatrice, Primois Charlotte, de Lara Christine Tunon, Debled Marc, de Mascarel Isabelle, Theillet Charles, Sévenet Nicolas, de Reynies Aurélien, MacGrogan Gaëtan, Longy Michel
Abstract excerpt
BACKGROUND: Despite entering complete remission after primary treatment, a substantial proportion of patients with early stage breast cancer will develop metastases. Prediction of such an outcome remains challenging despite the clinical use of several prognostic parameters. Several reports indicate that genomic instability, as reflected in specific chromosomal aneuploidies and variations in DNA content,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.