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Article

Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis.

European journal of cell biology - 1 Jan 2006

Schietke Ruth, Bröhl Dominique, Wedig Tatjana, Mücke Norbert, Herrmann Harald, Magin Thomas M

Abstract excerpt

To get new insights into the function of the intermediate filament (IF) protein vimentin in cell physiology, we generated two mutant cDNAs, one with a point mutation in the consensus motif in coil1A (R113C) and one with the complete deletion of coil 2B of the rod domain. In keratins and glia filament protein (GFAP), analogous mutations cause keratinopathies and Alexander disease, respectively. Both mutants...

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Identifiers

PMID: 16373170
DOI: 10.1016/j.ejcb.2005.09.019

Genes

GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis.PMID 16373170Read ↗

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