Filaments and phenotypes: cellular roles and orphan effects associated with mutations in cytoplasmic intermediate filament proteins

Abstract excerpt

Cytoplasmic intermediate filaments (IFs) surround the nucleus and are often anchored at membrane sites to form effectively transcellular networks. Mutations in IF proteins (IFps) have revealed mechanical roles in epidermis, muscle, liver, and neurons. At the same time, there have been phenotypic surprises, illustrated by the ability to generate viable and fertile mice null for a number of IFp-encoding genes, inclu...

Topics

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• Cells, Cultured
• Lipid Metabolism
• Mice
• Mice, Knockout
• Multigene Family
• Mutation
• Phenotype
• Vimentin

Identifiers and source

Literature Corpus work

93266410-4965-51e5-ae23-774271bbb1cc

DOI

10.12688/f1000research.19950.1