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Article

Dominant cataract formation in association with a vimentin assembly disrupting mutation.

Human molecular genetics - 15 Mar 2009

Müller Martin, Bhattacharya Shomi S, Moore Tony, Prescott Quincy, Wedig Tatjana, Herrmann Harald, Magin Thomas M

Abstract excerpt

Cataracts are characterized by an opacification of the eye lens, often caused by protein misfolding and aggregation. The intermediate filament protein vimentin, which is highly expressed in lens fiber cells and in mesenchymal tissues, is a main structural determinant in these cells forming a membrane-connected cytoskeleton. Additional functions of vimentin remain to be identified. Here, we demonstrate that a...

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Source

Identifiers

PMID: 19126778
DOI: 10.1093/hmg/ddn440

Genes

VIM

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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