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Article

The Witschi Hypothesis revisited after 35 years: genetic proof from SP-C BRICHOS domain mutations.

American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2013

Uhal Bruce D, Nguyen Hang

Abstract excerpt

Over 35 years ago, Wanda Haschek and Hanspeter Witschi published a theory for the pathogenesis of lung fibrosis that dared to challenge the longstanding view of lung fibrosis as an "inflammatory disease." On the basis of considerable experimental evidence, they proposed that lung fibrosis was initiated and propagated by microfoci of epithelial damage that, if unrepaired, upset the normal epithelial-fibroblast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24142519
DOI: 10.1152/ajplung.00246.2013
PMCID: PMC3882532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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