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Article

A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling.

BMC cell biology - 20 Nov 2010

Woischnik Markus, Sparr Christiane, Kern Sunčana, Thurm Tobias, Hector Andreas, Hartl Dominik, Liebisch Gerhard, Mulugeta Surafel, Beers Michael F, Schmitz Gerd, Griese Matthias

Abstract excerpt

BACKGROUND: Heterozygous mutations of SFTPC, the gene encoding surfactant protein C (SP-C), cause sporadic and familial interstitial lung disease (ILD) in children and adults. The most frequent SFTPC mutation in ILD patients leads to a threonine for isoleucine substitution at position 73 (I73T) of the SP-C preprotein (proSP-C), however little is known about the cellular consequences of SP-CI73T expression....

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Source

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Identifiers

PMID: 21092132
DOI: 10.1186/1471-2121-11-88
PMCID: PMC2994813

Genes

SFTPC
CCR2
CXCR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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