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Article

Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants.

The international journal of biochemistry & cell biology - 1 Jan 2012

Maguire Jean Ann, Mulugeta Surafel, Beers Michael F

Abstract excerpt

Epithelial cell dysfunction is now recognized as an important mechanism in the pathogenesis of interstitial lung diseases. Surfactant Protein C (SP-C), an alveolar type II cell specific protein, has contributed to this concept with the observation that heterozygous expression of SFTPC gene mutations are associated with chronic interstitial lung disease. We have shown that transient expression of aggregation prone...

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Source

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Identifiers

PMID: 22016030
DOI: 10.1016/j.biocel.2011.10.003
PMCID: PMC3243113

Genes

ATF4
ATF6
SFTPC

Provenance

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Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants.PMID 22016030Read ↗

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