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Article

Improving coiled coil stability while maintaining specificity by a bacterial hitchhiker selection system.

Journal of structural biology - 1 Jun 2014

Kükenshöner Tim, Wohlwend Daniel, Niemöller Christoph, Dondapati Padmarupa, Speck Janina, Adeniran Adebola V, Nieth Anita, Gerhardt Stefan, Einsle Oliver, Müller Kristian M, Arndt Katja M

Abstract excerpt

The design and selection of peptides targeting cellular proteins is challenging and often yields candidates with undesired properties. Therefore we deployed a new selection system based on the twin-arginine translocase (TAT) pathway of Escherichia coli, named hitchhiker translocation (HiT) selection. A pool of α-helix encoding sequences was designed and selected for interference with the coiled coil domain (CC)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24631970
DOI: 10.1016/j.jsb.2014.03.002

Genes

MITF
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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