Host mucin glycosylation plays a role in bacterial adhesion in lungs of individuals with cystic fibrosis.

Abstract excerpt

Malfunction of the cell surface glycoprotein, cystic fibrosis transmembrane conductance regulator, is the molecular hallmark of cystic fibrosis (CF), causing salt imbalance across the lung epithelium and biochemical and biophysical alterations of the mucous secretion and airway surfaces. Abnormal glycosylation of both secreted and membrane-tethered airway mucins in CF hosts are reported by a substantial body of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacterial Adhesion
• Share to Drug Design
• Share to Glycosylation