Article
Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates.
The American journal of physiology - 1 Feb 1994
Dosanjh A, Lencer W, Brown D, Ausiello D A, Stow J L
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is commonly mutated in cystic fibrosis to the delta F508 CFTR. CFTR has been shown to function as a adenosine 3',5'-cyclic monophosphate-dependent Cl- channel at the cell surface, and there is evidence to suggest that CFTR may also have a role in transmembrane Cl- conductance in intracellular membrane compartments. Studies using cells from cystic...
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