Post-translational modification by the Pgf glycosylation machinery modulates <i>Streptococcus mutans</i> physiology and virulence

Abstract excerpt

Streptococcus mutans is a keystone pathogen of dental caries, and the ability to form biofilms is essential for its pathogenicity. We identified a glycosylation machinery (Pgf) in S. mutans that post-translationally modifies two surface-associated adhesins, Cnm and WapA. The four pgf genes ( pgfS , pgfM1 , pgfE, and pgfM2 ) are part of S. mutans core genome and we hypothesized that the scope of Pgf goes bey...

Topics

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• Acids
• HIV/AIDS oral health manifestations
• Infective Endocarditis Diagnosis and Management
• Oral Health Pathology and Treatment
• Oral microbiology and periodontitis research
• Streptococcal Infections
• Streptococcal Infections and Treatments
• Streptococcus mutans

Identifiers and source

Literature Corpus work

5e451d78-e5ff-50a3-98f8-1e04010999de

DOI

10.1101/2022.10.10.511621