Article
Na+/H+ exchanger 1 is regulated via its lipid-interacting domain, which functions as a molecular switch: a pharmacological approach using indolocarbazole compounds.
Molecular pharmacology - 1 Jan 2014
Shimada-Shimizu Naoko, Hisamitsu Takashi, Nakamura Tomoe Y, Hirayama Noriaki, Wakabayashi Shigeo
Abstract excerpt
The plasma membrane Na(+)/H(+) exchanger 1 (NHE1) is rapidly activated in response to various stimuli. The membrane-proximal cytoplasmic region (∼60 residues), termed the lipid-interacting domain (LID), is an important regulatory domain of NHE1. Here, we used a pharmacological approach to further characterize the role of LID in the regulation of NHE1. Pharmacological analysis using staurosporine-like...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.