Strain-specific suppression of <i>microRNA-320</i> by carcinogenic <i>Helicobacter pylori</i> promotes expression of the antiapoptotic protein Mcl-1

Abstract excerpt

Helicobacter pylori is the strongest risk factor for gastric cancer, and strains harboring the cag pathogenicity island, which translocates the oncoprotein CagA into host cells, further augment cancer risk. We previously reported that in vivo adaptation of a noncarcinogenic H. pylori strain (B128) generated a derivative strain (7.13) with the ability to induce adenocarcinoma, providing a unique opportunity to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Helicobacter pylori-related gastroenterology studies
• Share to MicroRNA in disease regulation