<i>Helicobacter pylori</i> Infection, Oncogenic Pathways and Epigenetic Mechanisms in Gastric Carcinogenesis

Abstract excerpt

Chronic colonization of the human stomach by Helicobacter pylori, a Gram-negative bacterium, is the major cause of chronic gastritis, peptic ulcers and gastric cancer. Recent progress has elucidated important bacterial and host factors that are responsible for H. pylori-induced gastric inflammation and gastric malignancy. H. pylori cytotoxin-associated antigen A is the major oncogenic factor injected into host...

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