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Article

Genomic and phenotypic heterogeneity in prostate cancer.

Nature reviews. Urology - 1 Feb 2021

Haffner Michael C, Zwart Wilbert, Roudier Martine P, True Lawrence D, Nelson William G, Epstein Jonathan I, De Marzo Angelo M, Nelson Peter S, Yegnasubramanian Srinivasan

Abstract excerpt

From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having topographically and morphologically distinct tumour foci. Sequencing studies have revealed that individual tumour foci can arise as clonally distinct lesions with no shared driver gene alterations. This finding demonstrates that multiple genomically and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33328650
DOI: 10.1038/s41585-020-00400-w
PMCID: PMC7969494

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