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Article

Investigation of the binding network of IGF-I on the cavity surface of IGFBP4.

Journal of molecular modeling - 1 Dec 2013

Chen Xin, Zhu Shuyan, Duan Danhui, Wu Tao, Wang Qi

Abstract excerpt

Insulin-like growth factor-binding proteins (IGFBPs) control bioactivity and distribution of insulin-like growth factors (IGFs) through high-affinity complex of IGFBP and IGF. To get more insight into the binding interaction of IGF system, the site-directed mutagenesis and force-driving desorption methods were employed to study the interaction mechanism of IGFBP4 and IGF-I by molecular dynamics (MD) simulation....

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Share to Amino Acid Substitution
Share to Binding Sites
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mutagenesis, Site-Directed

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Source

Identifiers

PMID: 24132350
DOI: 10.1007/s00894-013-2020-8

Genes

IGFBP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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