Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.

PloS one - 1 Jan 2013

Minde David P, Radli Martina, Forneris Federico, Maurice Madelon M, Rüdiger Stefan G D

Abstract excerpt

Mutations in the central region of the signalling hub Adenomatous Polyposis Coli (APC) cause colorectal tumourigenesis. The structure of this region remained unknown. Here, we characterise the Mutation Cluster Region in APC (APC-MCR) as intrinsically disordered and propose a model how this structural feature may contribute to regulation of Wnt signalling by phosphorylation. APC-MCR was susceptible to proteolysis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hot Temperature

Share to Point Mutation

Share to Protein Structure, Secondary

Share to Protein Unfolding

Share to Proteolysis

Share to Wnt Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24130866
DOI: 10.1371/journal.pone.0077257
PMCID: PMC3793970

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutations.PMID 24130866Read ↗

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Semantic proximity Read ↗

The adenomatous polyposis coli protein 30 years on.Semantic proximity Read ↗

The 15-Amino Acid Repeat Region of Adenomatous Polyposis Coli Is Intrinsically Disordered and Retains Conformational Flexibility upon Binding β-Catenin.Semantic proximity Read ↗

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance.Semantic proximity Read ↗

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.Semantic proximity Read ↗

Assessing the pathogenicity of a variant of uncertain significance in the ALK gene in right-sided colon polyposis.Semantic proximity Read ↗

The ABC of APC.Semantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

APC mutations in human colorectal adenomas: analysis of the mutation cluster region with temperature gradient gel electrophoresis and clinicopathological features.Semantic proximity Read ↗

Truncation mutations abolish chromatin-associated activities of adenomatous polyposis coli.Semantic proximity Read ↗

APC shuttling to the membrane, nucleus and beyond.Semantic proximity Read ↗

Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.