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Assessing the pathogenicity of a variant of uncertain significance in the ALK gene in right-sided colon polyposis.

Cancer treatment and research communications - 1 Jan 2025

Serej Zeinab Aliyari, Naghinejad Maryam, Parvizpour Sepideh, Raeisi Mortaza, Jafarlou Vahid, Kalan Abbas Ebrahimi, Derakhshan Sima Mansoori, Taheri Mohammad

Abstract excerpt

Colorectal cancer (CRC) is the third most common cancer worldwide. Generally, Familial Adenomatous Polyposis (FAP) accounts for about 1 % to 2 % of all colorectal cancer cases. Mutations in the APC gene, inherited in an autosomal dominant manner, and mutations in the MUTYH gene, inherited in an autosomal recessive manner, are the primary causes of FAP. While, this study focuses on the pathogenicity assessment of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41067131
DOI: 10.1016/j.ctarc.2025.101010

Genes

ALK
APC
FAP
MUTYH

Variants

Provenance

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Assessing the pathogenicity of a variant of uncertain significance in the ALK gene in right-sided colon polyposis.PMID 41067131Read ↗

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