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Article

Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations

7 Mar 2011

Abstract excerpt

Many pathogens colonize different anatomical sites, but the selective pressures contributing to survival in the diverse niches are poorly understood. Group A Streptococcus (GAS) is a human-adapted bacterium that causes a range of infections. Much effort has been expended to dissect the molecular basis of invasive (sterile-site) infections, but little is known about the genomes of strains causing pharyngitis...

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PMID: 21383167
DOI: 10.1073/pnas.1016282108

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