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Evolution of the β-lactam-resistant Streptococcus pneumoniae PMEN3 clone over a 30 year period in Barcelona, Spain.

The Journal of antimicrobial chemotherapy - 1 Nov 2018

Càmara Jordi, Cubero Meritxell, Martín-Galiano Antonio J, García Ernesto, Grau Imma, Nielsen Jesper B, Worning Peder, Tubau Fe, Pallarés Román, Domínguez M Ángeles, Kilian Mogens, Liñares Josefina, Westh Henrik, Ardanuy Carmen

Abstract excerpt

Objectives: To analyse the epidemiology and genetic evolution of PMEN3 (Spain9V-156), a penicillin-non-susceptible clone of Streptococcus pneumoniae, causing invasive pneumococcal disease (IPD) in Barcelona during 1987-2016. Methods: WGS was performed on 46 representative isolates and the data were used to design additional molecular typing methods including partial MLST, PCR-RFLP and detection of surface-exposed...

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PMID: 30165641
DOI: 10.1093/jac/dky305

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