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Article

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

15 Oct 2013

Abstract excerpt

BACKGROUND: Aurora kinases are key regulators of cell cycle and represent new promising therapeutic targets in several human tumours. METHODS: Biological relevance of Aurora kinase-A and -B was assessed on osteosarcoma clinical samples and by silencing these genes with specific siRNA in three human osteosarcoma cell lines. In vitro efficacy of two Aurora kinases-targeting drugs (VX-680 and ZM447439) was evaluated...

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PMID: 24129234
DOI: 10.1038/bjc.2013.643

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