Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL.

doi:10.3390/ijms22010434

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Article

Inhibition of RANKL-Induced Osteoclastogenesis by Novel Mutant RANKL.

International journal of molecular sciences - 4 Jan 2021

Jang Yuria, Sohn Hong Moon, Ko Young Jong, Hyun Hoon, Lim Wonbong

Abstract excerpt

BACKGROUND: Recently, it was reported that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL and was shown to compete with RANK to bind RANKL and suppress canonical RANK signaling during osteoclast differentiation. The critical role of the protein triad RANK-RANKL in osteoclastogenesis has made their binding an important target for the development...

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PMID: 33406741
DOI: 10.3390/ijms22010434
PMCID: PMC7795528

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