RANKL/RANK control Brca1 mutation- .

doi:10.1038/cr.2016.69

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RANKL/RANK control Brca1 mutation- .

Cell research - 1 Jul 2016

Sigl Verena, Owusu-Boaitey Kwadwo, Joshi Purna A, Kavirayani Anoop, Wirnsberger Gerald, Novatchkova Maria, Kozieradzki Ivona, Schramek Daniel, Edokobi Nnamdi, Hersl Jerome, Sampson Aishia, Odai-Afotey Ashley, Lazaro Conxi, Gonzalez-Suarez Eva, Pujana Miguel A, Cimba For, Heyn Holger, Vidal Enrique, Cruickshank Jennifer, Berman Hal, Sarao Renu, Ticevic Melita, Uribesalgo Iris, Tortola Luigi, Rao Shuan, Tan Yen, Pfeiler Georg, Lee Eva Yhp, Bago-Horvath Zsuzsanna, Kenner Lukas, Popper Helmuth, Singer Christian, Khokha Rama, Jones Laundette P, Penninger Josef M

Abstract excerpt

Breast cancer is the most common female cancer, affecting approximately one in eight women during their life-time. Besides environmental triggers and hormones, inherited mutations in the breast cancer 1 (BRCA1) or BRCA2 genes markedly increase the risk for the development of breast cancer. Here, using two different mouse models, we show that genetic inactivation of the key osteoclast differentiation factor RANK...

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Identifiers

PMID: 27241552
DOI: 10.1038/cr.2016.69
PMCID: PMC5129883

Genes

BRCA1
BRCA2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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