Article
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2004
Tsuzuki Shinobu, Seto Masao, Greaves Mel, Enver Tariq
Abstract excerpt
The t(12;21) translocation, which generates the TEL-AML1 (ETV6-RUNX1) fusion gene, is the most common structural chromosome change in childhood cancer and is exclusively associated with the common B cell precursor subset of acute lymphoblastic leukemia (ALL). Evidence suggests that the translocation usually occurs in utero during fetal hemopoiesis and most probably constitutes an initiating or first-hit mutation...
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