Article
Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling pathway.
Stem cells (Dayton, Ohio) - 1 Mar 2014
Saoncella Stefania, Tassone Beatrice, Deklic Erika, Avolio Fabio, Jon Cristina, Tornillo Giusy, De Luca Elisa, Di Iorio Enzo, Piva Roberto, Cabodi Sara, Turco Emilia, Pandolfi Pier Paolo, Calautti Enzo
Abstract excerpt
Signals downstream of Akt can either favor or oppose stem cell (SC) maintenance, but how this dual role can be achieved is still undefined. Using human limbal keratinocyte stem cells (LKSCs), a SC type used in transplantation therapies for corneal regeneration, we show that Akt signaling is prominent in SC populations both in vivo and in vitro, and that Akt1 promotes while Akt2 opposes SC self-renewal....
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