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Article

Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver

11 Oct 2013

Abstract excerpt

UNLABELLED: Approximately 50% of patients with chronic hepatitis C (CHC) have ongoing expression of interferon stimulated genes (ISGs) in the liver. It is unclear why this endogenous antiviral response is inefficient in eradicating the infection. Several viral escape strategies have been identified in vitro, including inhibition of interferon (IFN) induction and ISG messenger RNA (mRNA) translation. The in vivo...

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PMID: 24122862
DOI: 10.1002/hep.26770

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