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Article

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

1 Dec 2010

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) replication in primary liver cells is less robust than that in hepatoma cell lines, suggesting that innate antiviral mechanisms in primary cells may limit HCV replication or spread. Here we analyzed the expression of 47 genes associated with interferon (IFN) induction and signaling following HCV infection of primary human fetal liver cell (HFLC) cultures from 18 different...

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PMID: 21800339
DOI: 10.1002/hep.24580

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