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Article

ISG56 and IFITM1 Proteins Inhibit Hepatitis C Virus Replication

6 Oct 2011

Abstract excerpt

Hepatitis C virus (HCV) often leads to persistent infection. Interferon (IFN) and IFN-stimulated genes (ISGs) are amplified during HCV infection but fail to eliminate virus from the liver in a large number of infected patients. We have observed previously that HCV infection induces IFN-β production in immortalized human hepatocytes (IHH) as early as 24 h after infection, although virus replication is not...

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PMID: 21976647
DOI: 10.1128/jvi.05633-11

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