A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus.

doi:10.1158/1055-9965.EPI-15-0507

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Article

A newly identified susceptibility locus near FOXP1 modifies the association of gastroesophageal reflux with Barrett's esophagus.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2015

Dai James Y, de Dieu Tapsoba Jean, Buas Matthew F, Onstad Lynn E, Levine David M, Risch Harvey A, Chow Wong-Ho, Bernstein Leslie, Ye Weimin, Lagergren Jesper, Bird Nigel C, Corley Douglas A, Shaheen Nicholas J, Wu Anna H, Reid Brian J, Hardie Laura J, Whiteman David C, Vaughan Thomas L

Abstract excerpt

BACKGROUND: Important risk factors for esophageal adenocarcinoma and its precursor, Barrett's esophagus, include gastroesophageal reflux disease, obesity, and cigarette smoking. Recently, genome-wide association studies have identified seven germline single-nucleotide polymorphisms (SNP) that are associated with risk of Barrett's esophagus and esophageal adenocarcinoma. Whether these genetic susceptibility loci...

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Identifiers

PMID: 26377193
DOI: 10.1158/1055-9965.EPI-15-0507
PMCID: PMC4816532

Genes

FOXP1
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Source receipt: pubmed, retrieved 7 Sept 2026.

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