Article
Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma.
Cancer medicine - 1 Nov 2015
Becker Jessica, May Andrea, Gerges Christian, Anders Mario, Veits Lothar, Weise Katharina, Czamara Darina, Lyros Orestis, Manner Hendrik, Terheggen Grischa, Venerito Marino, Noder Tania, Mayershofer Rupert, Hofer Jan-Hinnerk, Karch Hans-Werner, Ahlbrand Constantin J, Arras Michael, Hofer Sebastian, Mangold Elisabeth, Heilmann-Heimbach Stefanie, Heinrichs Sophie K M, Hess Timo, Kiesslich Ralf, Izbicki Jakob R, Hölscher Arnulf H, Bollschweiler Elfriede, Malfertheiner Peter, Lang Hauke, Moehler Markus, Lorenz Dietmar, Müller-Myhsok Bertram, Ott Katja, Schmidt Thomas, Whiteman David C, Vaughan Thomas L, Nöthen Markus M, Hackelsberger Andreas, Schumacher Brigitte, Pech Oliver, Vashist Yogesh, Vieth Michael, Weismüller Josef, Neuhaus Horst, Rösch Thomas, Ell Christian, Gockel Ines, Schumacher Johannes
Abstract excerpt
The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) and Barrett's esophagus. They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1. Furthermore, they replicated an association at the FOXF1 gene that has been previously found in a GWAS on Barrett's...
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