Article
Dynamics of coexisting HCMV-UL97 and UL54 drug-resistance associated mutations in patients after haematopoietic cell transplantation.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2013
Göhring Katharina, Wolf Dana, Bethge Wolfgang, Mikeler Elfriede, Faul Christoph, Vogel Wichard, Vöhringer Matthias C, Jahn Gerhard, Hamprecht Klaus
Abstract excerpt
BACKGROUND: Resistance to antiviral drugs can be a severe problem in transplant recipients. Mutations in the HCMV phosphotransferase-gene (UL97) and the polymerase-gene (UL54) are responsible for resistance against ganciclovir (GCV), cidofovir (CDV) and foscarnet (PFA). Most frequently mutations in the UL97-gene are associated with resistance to GCV. Resistance against PFA and CDV is associated to mutations in...
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