Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation.

doi:10.3389/fimmu.2020.604206

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Article

Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation.

Frontiers in immunology - 1 Jan 2020

Papa Riccardo, Penco Federica, Volpi Stefano, Gattorno Marco

Abstract excerpt

A growing number of monogenic immune-mediated diseases have been related to genes involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate cytoskeleton defects to autoinflammatory diseases and primary immunodeficiencies. We reviewed the pathways of actin cytoskeleton remodeling in order to identify inflammatory and immunological manifestations associated to pathological variants. We...

Topics

Actin Cytoskeleton
Animals
Autoimmunity
Genetic Predisposition to Disease
Humans
Immunologic Deficiency Syndromes
Inflammation
Mutation
Phenotype
Signal Transduction

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Identifiers

PMID: 33488606
DOI: 10.3389/fimmu.2020.604206
PMCID: PMC7817698

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